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Neuroscience
Epilepsy medication shows promise in reducing cocaine use in rats
Substance use disorders are notoriously difficult to treat, as it is challenging to intervene in a drugs' effect on the brain's reward pathway without interfering with the pathway's normal function. In a University of Arizona ...
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Genetics
A universal gene therapy for Diamond-Blackfan anemia is poised for clinical trials
Efforts to develop a gene therapy for Diamond-Blackfan anemia (DBA)—a rare, life-threatening disorder in which bone marrow cannot make mature, functioning red blood cells—have been hampered by the fact that at least 30 ...
3 hours ago
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Medical research news
Experiments detail how cancer cells fend off starvation and death from chemotherapy
Laboratory experiments with cancer cells have revealed two ways in which tumors evade drugs designed to starve and kill them.
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'Remarkable global progress': HIV cases and deaths declining
The number of new HIV infections and deaths has fallen across the world, marking significant progress in the fight against the disease.
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Study reveals genetic drivers of early onset type 2 diabetes in South Asians
A genetic predisposition to having lower insulin production and less healthy fat distribution are major causes of early-onset type 2 diabetes in British Asian people. According to new research from Queen Mary University of ...
3 hours ago
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Popular diabetes and obesity drugs also protect kidneys, study shows
The biggest and most comprehensive analysis of glucagon-like peptide-1 (GLP-1) receptor agonists on kidney and cardiovascular outcomes shows they have significant benefits in people with and without diabetes. The findings ...
13 hours ago
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New malaria vaccine shows high protection in clinical trial
Researchers at Leiden University Medical Center and Radboud University Medical Center in the Netherlands have demonstrated promising safety and efficacy of a late-liver-stage attenuated malaria parasite vaccine in a small ...
Researchers uncover potential new biomarker for psychosis diagnosis
The current standard of care for psychosis is a diagnostic interview, but what if it could be diagnosed before the first symptom emerged? Researchers at the Del Monte Institute for Neuroscience at the University of Rochester ...
16 hours ago
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Clinical trial finds combined procedures better for persistent atrial fibrillation
Research conducted across 12 hospitals in China has discovered that combining linear ablation with ethanol infusion via the vein of Marshall (EIVOM) alongside pulmonary vein isolation (PVI) significantly improves sinus rhythm ...
Reward-based learning—neuroscientists demonstrate dopamine and serotonin work in opposition to shape learning
If you've heard of two of the brain's chemical neurotransmitters, it's probably dopamine and serotonin. Never mind that glutamate and GABA do most of the work—it's the thrill of dopamine as the "pleasure chemical" and serotonin ...
17 hours ago
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Research links wildfire smoke exposure with increased dementia risk
As Baby Boomers hit retirement, about 1 in 6 Americans is now over the age of 65. The number of Americans living with dementia is projected to skyrocket—but the proportion of older Americans who develop dementia has actually ...
16 hours ago
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Nasal spray drug shows promise in Alzheimer's research
A future treatment for Alzheimer disease may involve a nasal spray. Researchers at Università Cattolica and Fondazione Policlinico Universitario A. Gemelli IRCCS have discovered that by inhibiting the brain enzyme S-acyltransferase ...
17 hours ago
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Study reveals new neuropeptide involved in controlling calorie expenditure
An international team of researchers has discovered a new component of the peripheral nervous system that acts by increasing energy metabolism in the body. The finding paves the way for the development of simpler and cheaper ...
17 hours ago
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Key brain circuit for female sexual rejection uncovered
A team from the Champalimaud Foundation (CF) has pinpointed a critical neural circuit for sexual rejection, identifying a set of brain cells that play a crucial role in determining whether a female accepts or rejects mating ...
19 hours ago
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Cells use backup mechanism to recognize potential invaders when usual RNA editing process fails, study finds
Our cells need to be able to recognize potential invaders as a threat, the key function of the body's innate immune system. Sometimes this process fails, causing the body to react to its own cells, leading to autoinflammatory ...
16 hours ago
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How race impacts patients' response to cancer immunotherapy: Treatment proves effective for Black patients
Clinical trials testing cancer immunotherapies have significantly under-represented Black patients. So while these treatments have resulted in dramatically improved outcomes for some patients, researchers from the University ...
17 hours ago
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Researchers identify gene signature for high-risk form of T-cell acute lymphoblastic leukemia
Researchers from Children's Hospital of Philadelphia (CHOP) have discovered the underlying biology that identifies a subset of patients with acute lymphoblastic leukemia who have a higher risk version of the disease and are ...
17 hours ago
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Bioengineering strategy uses immune-protected beta cell transplant to advance type 1 diabetes care
Regenerative medicine holds the extraordinary promise that future patients in need of new cells, tissues or organs will no longer have to rely on donors. Organ shortages and cell type mismatches will become past problems, ...
17 hours ago
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Hunger hormone study suggests a novel role in the development of neural circuits
Researchers from the Vanderbilt University School of Medicine Basic Sciences have uncovered the first example of activity-dependent development of hypothalamic neural circuitry.
17 hours ago
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Chromosomal chaos promotes therapy resistance in leukemia cells and opens up new treatment approaches
Chromosomal instability plays a crucial role in the progression of cancer: it shapes the properties of tumor cells and drives the development of therapy resistance. Scientists from the German Cancer Research Center (DKFZ), ...
18 hours ago
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